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Gen Sobue Selected Research

Neoplasms (Cancer)

1/2015Evaluation of resting state networks in patients with gliomas: connectivity changes in the unaffected side and its relation to cognitive function.
1/2015Efficacy of intravenous immunoglobulin for treatment of Lambert-Eaton myasthenic syndrome without anti-presynaptic P/Q-type voltage-gated calcium channel antibodies: a case report.
1/2013[Intracranial germinoma masquerading as a granulomatous inflammation, diagnostic failure after brain biopsy].
1/2013Paraneoplastic neuropathy.
1/2013[MicroRNA in neurodegenerative disorders].
10/2011Paraneoplastic neuropathy: wide-ranging clinicopathological manifestations.
7/2008Rapidly developing weakness mimicking Guillain-Barré syndrome in beriberi neuropathy: two case reports.
11/2006Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG).
8/2006Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein.

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Gen Sobue Research Topics

Disease

85X-Linked Bulbo-Spinal Atrophy
11/2023 - 08/2002
61Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
07/2023 - 01/2002
41Neurodegenerative Diseases (Neurodegenerative Disease)
01/2023 - 12/2002
36Motor Neuron Disease (Primary Lateral Sclerosis)
01/2020 - 03/2003
26Parkinson Disease (Parkinson's Disease)
12/2021 - 06/2005
22Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
01/2022 - 04/2002
22Polyneuropathies (Polyneuropathy)
01/2022 - 04/2002
17Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
04/2021 - 03/2012
16Disease Progression
01/2022 - 05/2006
15Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy)
12/2018 - 11/2002
15Atrophy
11/2018 - 06/2005
12Alzheimer Disease (Alzheimer's Disease)
05/2022 - 08/2002
12Muscle Weakness
03/2018 - 06/2006
11Pain (Aches)
01/2018 - 11/2003
10Muscular Atrophy (Muscle Atrophy)
01/2020 - 11/2005
9Demyelinating Diseases (Demyelinating Disease)
02/2021 - 11/2010
9Neuromuscular Diseases (Neuromuscular Disease)
01/2020 - 01/2015
9Neoplasms (Cancer)
01/2015 - 08/2006
8Orthostatic Hypotension (Postural Hypotension)
12/2018 - 06/2010
7Sarcoma (Soft Tissue Sarcoma)
11/2022 - 05/2014
7Inflammation (Inflammations)
03/2022 - 11/2002
7Dementia (Dementias)
01/2021 - 05/2003
6Peripheral Nervous System Diseases (PNS Diseases)
11/2023 - 06/2011
6Churg-Strauss Syndrome (Allergic Angiitis)
03/2022 - 10/2013
6Paraproteinemias (Monoclonal Gammopathy)
12/2020 - 01/2015
6Huntington Disease (Huntington's Disease)
01/2020 - 06/2004
6Spinocerebellar Ataxias (Spinocerebellar Ataxia)
01/2020 - 06/2004
6Amyloidosis
12/2018 - 12/2009
6Thiamine Deficiency
03/2015 - 07/2003
5Microscopic Polyangiitis
11/2023 - 10/2013
5Deglutition Disorders (Dysphagia)
01/2022 - 06/2006
5Nervous System Heredodegenerative Disorders
01/2022 - 11/2006
5Frontotemporal Dementia (Semantic Dementia)
01/2020 - 08/2009
4Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
05/2022 - 11/2004
4Cognitive Dysfunction
01/2020 - 06/2014
4Speech Disorders (Cluttering)
01/2020 - 05/2015
4Dysarthria (Spastic Dysarthria)
12/2019 - 06/2006
3Ischemic Stroke
08/2023 - 01/2016
3TDP-43 Proteinopathies
03/2023 - 03/2012
3Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
03/2022 - 10/2013
3Necrosis
01/2021 - 09/2010
3Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy)
01/2020 - 05/2008
3Vasculitis (Vasculitides)
01/2020 - 10/2015
3Stroke (Strokes)
01/2020 - 01/2016
3Transthyretin-Related Hereditary Amyloidosis
01/2019 - 11/2011
3Headache (Headaches)
01/2018 - 01/2009

Drug/Important Bio-Agent (IBA)

58Androgen Receptors (Androgen Receptor)IBA
11/2023 - 08/2002
53polyglutamineIBA
11/2023 - 08/2002
36Proteins (Proteins, Gene)FDA Link
12/2022 - 01/2003
20Intravenous Immunoglobulins (IVIG)FDA Link
11/2023 - 11/2005
17Prealbumin (Transthyretin)IBA
12/2018 - 04/2002
15Superoxide Dismutase-1IBA
01/2022 - 08/2002
13Biomarkers (Surrogate Marker)IBA
10/2022 - 03/2012
12DNA-Binding Proteins (DNA Binding Protein)IBA
12/2022 - 08/2009
12Amyloid (Amyloid Fibrils)IBA
05/2022 - 12/2009
12AndrogensIBA
01/2022 - 04/2007
11AntibodiesIBA
12/2020 - 02/2011
10RNA (Ribonucleic Acid)IBA
01/2020 - 01/2013
9RNA-Binding Proteins (RNA-Binding Protein)IBA
11/2022 - 01/2013
9Proteasome Endopeptidase Complex (Proteasome)IBA
01/2021 - 11/2002
8Messenger RNA (mRNA)IBA
11/2022 - 04/2002
8Immunoglobulins (Immunoglobulin)IBA
01/2022 - 02/2014
8Immunoglobulin G (IgG)IBA
12/2020 - 04/2013
7Leuprolide (Lupron)FDA LinkGeneric
01/2022 - 06/2003
7HizentraIBA
01/2022 - 01/2016
7UbiquitinIBA
01/2021 - 11/2002
73-Iodobenzylguanidine (Iobenguane)IBA
12/2018 - 12/2007
6Testosterone (Sustanon)FDA Link
01/2022 - 08/2002
6Immunoglobulin M (IgM)IBA
12/2020 - 09/2010
5Protein Isoforms (Isoforms)IBA
11/2022 - 12/2012
5Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
03/2022 - 09/2010
5DNA (Deoxyribonucleic Acid)IBA
01/2021 - 01/2012
5Myelin-Associated GlycoproteinIBA
12/2020 - 09/2010
5AutoantibodiesIBA
12/2018 - 10/2011
5Thiamine (Aneurin)FDA Link
03/2015 - 11/2004
5Prion ProteinsIBA
12/2009 - 06/2005
4EdaravoneIBA
07/2023 - 12/2014
4Acetates (Acetic Acid Esters)FDA Link
01/2022 - 08/2009
4Nerve Growth Factors (Neurotrophins)IBA
01/2020 - 04/2002
4Levodopa (L Dopa)FDA LinkGeneric
06/2019 - 01/2008
4CreatinineIBA
01/2018 - 09/2012
4Adrenal Cortex Hormones (Corticosteroids)IBA
01/2018 - 08/2003
4Folic Acid (Vitamin M)FDA LinkGeneric
01/2017 - 07/2012
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2016 - 03/2004
4alpha-SynucleinIBA
01/2014 - 08/2003
4CytokinesIBA
04/2012 - 04/2002
4Codon (Codons)IBA
01/2010 - 11/2006
4Mutant Proteins (Protein, Mutant)IBA
12/2009 - 08/2006
3Therapeutic UsesIBA
01/2023 - 07/2014
3RiluzoleFDA LinkGeneric
01/2023 - 08/2008
3Sodium Channels (Sodium Channel)IBA
12/2020 - 11/2015
3Complement System Proteins (Complement)IBA
01/2020 - 11/2010

Therapy/Procedure

48Therapeutics
03/2023 - 08/2003
10Activities of Daily Living (ADL)
08/2023 - 06/2006
8Deep Brain Stimulation
12/2021 - 01/2013
8Molecular Targeted Therapy
07/2012 - 08/2006
4Stem Cell Transplantation
08/2021 - 01/2006
4Sympathectomy (Sympathectomies)
04/2014 - 12/2007
4Liver Transplantation
11/2013 - 11/2011
3Tracheostomy
01/2022 - 06/2015